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Here, we design, synthesize, and biologically test covalent cyclic peptides that irreversibly target the TRF2 TRFH domain. We identify APOD53 as our most promising compound, as it consistently induces a telomeric DNA damage response in cancer cell lines.

TRF1 and TRF2 are key components of vertebrate telomeres. They bind to double-stranded telomeric DNA as homodimers. Dimerization involves the TRF homology (TRFH) domain, which also mediates interactions with other telomeric proteins.

These studies concerning both mammalian and Schizosaccharomyces pombe proteins reveal unexpected structural conservation of a motif called TRFH (Telomeric Repeat Factors Homology) domain between...

Aided by a novel crystal system of TRF1 TRFH , we characterised fragments binding in a hotspot at the TRF1:TIN2 interface; these will serve as a starting point for the structure-guided development of potent inhibitors of TRF1 protein:protein interactions to disrupt shelterin complex assembly.

RCSB PDB - 9HCZ: Crystal structure of human TRF1 TRFH domain in complex ...

Review the latest Morningstar rating and analysis on the TRFHX fund to determine if it is the right investment decision for your goals.

Microsoft Teams Blog Welcome to the Microsoft Teams Blog! Learn best practices, news, and trends directly from the team behind Microsoft Teams.

Welcome to the Microsoft Teams Blog! Learn best practices, news, and trends directly from the team behind Microsoft Teams.

Our Personality Behind the Profile series, showcasing some of the most influential and popular social media profiles in the fire service looked at a dozen influencers. Robert Policht dives into how he ...